JUROX PROMECTIN PLUS HORSE PASTE

Combines abamectin, a member of the avermectin group of compounds, with praziquantel. Abamectin is a highly efficient broad spectrum wormer with activity against gastrointestinal, pulmonary and cutaneous nematodes, bots and external parasites. It acts by binding selectively to glutamate-gated chloride channels in invertebrate nerve and muscle cells, and causes depolarisation of the nerve and muscle cells which leads to paralysis and death of the parasites. Abamectin has good activity against both mature and immature stages of the nematodes. In the horse this is particularly of advantage with Strongylus vulgaris, so reducing the incidence of verminous arteritis and associated colic. Abamectin has been demonstrated to be safe when used at twice the recommended dose in foals, pregnant mares and breeding stallions, and up to five times the recommended dose in adults. Praziquantel is an isoquinoline pyrazine which is readily absorbed from the gastrointestinal tract and excreted in the bile and urine. It has an extremely high activity against all species of tapeworms, is absorbed readily and rapidly by cestodes (tapeworms) and causes a rapid tetanic spasm of the musculature of the parasite and vacuoles to appear in the tegument. In the tapeworm there is first rapid contraction of the muscles and then a rise in the cell membrane calcium permeability which subsequently leads to muscle paralysis. Praziquantel has been shown to have a wide safety margin